Endocrine Abstracts

Background: The exon-3 deletion in the growth hormone receptor gene (d3 GHR) leads to an enhanced GH signal transduction. Acromegalic patients with the d3 GHR genotype could be expected to have more marked clinical or biochemical manifestations for a given GH level than those with the wild (fl) type GHR. We studied acromegalic patients for clinical and/or biochemical disease recurrence after surgery in relation to GHR genotype status to assess whether d3 GHR influences the rel...